Alfred Collins’ game-saving play anchored a 49ers upset and highlighted the value of disruptive depth at defensive tackle. Drake Maye connected on multiple big-time throws, illustrating how his growth is lifting the Patriots’ late-season ceiling with Diggs as a marquee downfield option. Week 5’s standouts were broken down with a focus on fantasy impact and betting angles, while PFF+ tools offer new in-season projections and prop insights to sharpen rosters and bets.

Jalen Pitre’s backfield coverage and diving interception signaled Texans’ defensive instincts improving in critical moments, and Aidan Hutchinson’s sack-forced fumble underscored Lions’ aggressive edge pressure. Across the league, the week’s top plays form a blueprint for where fantasy and props bettors should focus as the season unfolds, aided by premium stats and grading breakdowns.

San Francisco’s Week 5 win over the Rams comes with a growing injury toll ahead of Week 6 vs Tampa Bay. Upton Stout’s ankle sprain isn’t high-grade, but it creates uncertainty in the 49ers’ secondary. Kalia Davis broke a hand and will undergo surgery, likely thinning interior push. Yetur Gross-Matos and Alfred Collins are limited by hamstring and knee injuries, respectively. Malik Mustapha’s ACL injury opens a 21-day practice window, while George Kittle is a distant (week-to-week) option for Week 6 with hopes for Week 7. SF will lean on depth as it prepares for the Buccaneers.

Injuries forced San Francisco into unfamiliar roles, but they beat Los Angeles 26-23 to seize the NFC West lead. Alfred Collins forced and recovered a goal-line fumble, and Kendrick Bourne piled up 142 yards on 10 catches as Mac Jones steered the offense in Purdy's toe-injury absence.

Stafford threw for 389 yards and 3 TDs, but the Rams stalled late; Kyren Williams fumbled near the goal line, and Puka Nacua kept the air busy with 10 receptions for 76 yards and a TD. The 49ers’ defense held on a crucial OT stop, setting up a Week 6 clash with Tampa Bay.

Undermanned but unflappable, San Francisco edged the Rams 26-23 as Mac Jones thrived with a patchwork receiving corps. Bourne logged 10 receptions for 142 yards, Jones threw for 342 yards and 2 TDs with no picks, and the defense closed it out with a late stand. Purdy is week-to-week, but Jones's showing keeps fantasy options alive behind SF's depth.